2391_BIOQUELL HPV VS CD W PAPER_HC001-MKT-048 Rev 1 US.indd
ثبت نشده
چکیده
development of aseptic techniques. Pasteur’s work in 1861 on spoilage of foodstuffs by microorganisms, and the subsequent development of pasteurization, laid the foundations for the modern principles of aseptic technique and manufacture. Whether it is employed in hospitals to prevent patient infection, food processing to prolong shelf-life or pharmaceutical manufacturing to ensure product integrity, the ability to bio-decontaminate whole rooms, enclosures or pieces of equipment is a vital component in the maintenance of an aseptic environment. When reviewing the best method of bio-decontamination to apply for any given application, it should be considered on its merit in a number of areas such as safety, efficacy, ease of use and compatibility. Due to those factors, using formaldehyde (one of the older bio-decontamination methods) is becoming increasingly rare as safer methods are sought. Copious data exists for a number of alternative methods of biodecontamination; this paper reviews the available information and compares/contrasts two of the more widely implemented methods, hydrogen peroxide vapor (HPV) and chlorine dioxide (CD). Bio-decontamination processes compared: hydrogen peroxide vapor and chlorine dioxide WHITE PAPER SCIENCE DRIVEN BIO-DECONTAMINATION LS001-MKT-048 Rev 1 US
منابع مشابه
Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.
We investigated the mitochondrial toxicity of the lipophilic cation, MKT-077, and the role of mitochondria in selective malignant cell killing by this compound by examining the effect of MKT-077 on mitochondrial structure and function in treated cells and in isolated organelles. Results of this study demonstrate changes in mitochondrial ultrastructure that are induced by MKT-077 treatment in ca...
متن کاملMKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.
MKT-077 (formerly known as FJ-776) is a newly synthesized, highly water-soluble ( > 200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems. In culture, MKT-077 inhibits the growth of five human cancer cell lines (colon carcinoma CX-1, breast carcinoma MCF-7, pancreatic carcinoma (CRL 1420, bladder transitional cell carcinoma EJ, and melanoma LOX) ...
متن کاملA phase I and pharmacokinetic study of the mitochondrial-specific rhodacyanine dye analog MKT 077.
This Phase I study was performed to evaluate the tolerability and pharmacokinetic behavior of MKT-077, a water soluble rhodacyanine dye analogue, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. Thirteen patients with advanced solid malignancies were treated with MKT-077 administered as a 30-min i.v. infusion wee...
متن کاملUptake Rate of Cationic Mitochondrial Inhibitor MKT-077 Determines Cellular Oxygen Consumption Change in Carcinoma Cells
OBJECTIVE Since tumor radiation response is oxygen-dependent, radiosensitivity can be enhanced by increasing tumor oxygenation. Theoretically, inhibiting cellular oxygen consumption is the most efficient way to increase oxygen levels. The cationic, rhodacyanine dye-analog MKT-077 inhibits mitochondrial respiration and could be an effective metabolic inhibitor. However, the relationship between ...
متن کاملPrevalence, Clinicopathological Characteristics, and Outcome of Human Papillomavirus-Associated Oropharyngeal Cancer in Southern Chinese Patients.
BACKGROUND Although the global incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing, there is little information on southern Chinese population available. METHODS We analyzed 207 patients which constituted 63.5% of all newly diagnosed OPSCC in Hong Kong during a 5-year period from 2005 to 2009. RESULTS We used E6/7 mRNA as a marker o...
متن کامل